Malvern MicroCal PEAQ-ITC Automated Ultrasensitive Isothermal Titration Calorimeter
Description:
Isothermal titration calorimetry (ITC) is an efficient and essential technique in the study of protein interactions and drug discovery. It directly measures the heat released or absorbed during the binding events of any two biomoleculars. Malvern MIcroCal PEAQ-ITC automated is a fully automated ITC and allows unattended operation. It offers label-free in solution measurements, eliminates the adverse effect of altering biomolecules. In a direct and single experiment, ITC allows the measurement of binding affinity and thermodynamics, resulting in an accurate determination of binding constants (KD), reaction stoichiometry (n), enthalpy (ΔH) and entropy (ΔS).
Specifications:
- Measurement parameter: affinity (KD), enphalpy (ΔH), entropy (ΔS) and stoichiometry (n)
- Sample capacity: 384 (4 x 96-well plates)
- Sample volume: 370 µl
- Cell volume: 200 µl
- Injection syringe volume: 40 µl
- Throughput: Up to 42 reactions per 24 hours
Applications:
- Characterising biomolecular interactions
- Studying the interaction of any two biomolecules
- Drug discovery
Location: Y729
Hourly rate: $49 (internal users); $98 (collaborators); $245 (external users)
